2. Signaling Pathways
  3. Immunology/Inflammation
  4. Interleukin Related

Interleukin Related

IL

Interleukin Related

Related Products

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Interleukins are a group of cytokines (secreted proteins and signaling molecules) that were first seen to be expressed by white blood cells (leukocytes). The function of the immune system depends in a large part on interleukins, and rare deficiencies of a number of them have been described, all featuring autoimmune diseases or immune deficiency. The majority of interleukins are synthesized by helper CD4 T lymphocytes, as well as through monocytes, macrophages, and endothelial cells. They promote the development and differentiation of T and B lymphocytes, and hematopoietic cells. Interleukin receptors on astrocytes in the hippocampus are also known to be involved in the development of spatial memories in mice.

Interleukin Related Isoform Specific Products:

Interleukin Related Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-RS06730
    Il2 Rat Pre-designed siRNA Set A
    		Inhibitor

    Il2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Il2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Il2 Rat Pre-designed siRNA Set A
    Il2 Rat Pre-designed siRNA Set A
  • HY-113271
    5-Androstenetriol
    		Activator
    5-Androstenetriol is a systemic radiation protector that can boost the host's immunity, leading to increased resistance to infections. 5-Androstenetriol can raise levels of IL-2, IL-3, and IFN, while countering the immunosuppressive effects of Hydrocortisone (HY-N0583).
    5-Androstenetriol
  • HY-N14039
    Pinus pinaster bark extract
    		Activator
    Pinus pinaster bark extract is extracted from the bark of pine bark with antioxidant, anti-inflammatory and neuroprotective effects. Pinus pinaster bark extract increases toll-like receptor (TLR) activity, inducing production of IL-10.
    Pinus pinaster bark extract
  • HY-173317
    STING-IN-13
    		Inhibitor
    STING-IN-13 is a selective STING inhibitor. STING-IN-13 can effectively inhibit downstream signaling of the STING pathway and inhibit STING-mediated inflammation. STING-IN-13 has low toxicity and can be used to study STING-related inflammatory and autoimmune diseases.
    STING-IN-13
  • HY-159060
    Coriolus Versicolor Extract
    		Inhibitor
    Coriolus Versicolor Extract is a biological response modifier (BRM) with anti-cancer and anti-migratory properties. Coriolus Versicolor Extract can also inhibit the expression of tumorigenic factors associated with inflammation and can be used in cancer research.
    Coriolus Versicolor Extract
  • HY-149087
    MR2938
    		Inhibitor
    MR2938 is a potent AChE inhibitor, with an IC50 of 5.04 μM. MR2938 also suppresses NO production obviously (IC50 = 3.29 μM). MR2938 suppresses the neuroinflammation through blocking MAPK/JNK and NF-κB signaling pathways. MR2938 can be used for Alzheimer’s disease (AD) research.
    MR2938
  • HY-P2630
    Suc-YVAD-pNA
    Suc-YVAD-pNA is a substrate of ICE. Interleukin-1β-converting enzyme (ICE) is a cysteine protease responsible for the cleavage of pre-interleukin-1β (pre-IL-1β) to the mature cytokine and a member of a family of related proteases (the caspases).
    Suc-YVAD-pNA
  • HY-B1971R
    Deltamethrin (Standard)
    Deltamethrin (Standard) is the analytical standard of Deltamethrin. This product is intended for research and analytical applications. Deltamethrin (Decamethrin) is an orally active synthetic pyrethroid insecticide. Deltamethrin induces oxidative stress and results in inflammation and apoptosis via inhibiting Nrf2/HO-1 pathway. Deltamethrin has an anticancer effect by inducing apoptosis. Deltamethrin can be used extensively in pest control.
    Deltamethrin (Standard)
  • HY-168971
    Paeoniflorin-6′-O-benzene sulfonate
    		Inhibitor
    Paeoniflorin-6′-O-benzene sulfonate (CP-25) is the inhibitor for G protein-coupled receptor kinase 2 (GRK2) that inhibits the translocation of GRK2 to the cell membrane, inhibits JAK1/STAT3 signaling pathway. Paeoniflorin-6′-O-benzene sulfonate inhibits IL-17A/CXCL2-induced proliferation of HaCaT. Paeoniflorin-6′-O-benzene sulfonate reduces the levels of inflammatory factors and chemokines such as IL-17A, IL-17F, IFN-γ, TNF-α, IL-22, IL-23, CXCL2, CXCL3 and CXCL9, alleviates Imiquimod (HY-B0180)-induced psoriasis in mouse model.
    Paeoniflorin-6′-O-benzene sulfonate
  • HY-144684
    PDE4-IN-8
    		Inhibitor
    PDE4-IN-8 (Example 5) is a potent PDE4 inhibitor with an IC50 of 0.93 nM for PDE4B2.PDE4-IN-8 has little effect on IL13 (IC50=4.04 nM), IL4 (IC50=36.33 nM), IFNy (IC50=2394 nM).
    PDE4-IN-8
  • HY-RS06695
    IL17A Human Pre-designed siRNA Set A
    		Inhibitor

    IL17A Human Pre-designed siRNA Set A contains three designed siRNAs for IL17A gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
    IL17A Human Pre-designed siRNA Set A
    IL17A Human Pre-designed siRNA Set A
  • HY-159874
    KRN7000 analog 2
    		Activator
    KRN7000 analog 2 is a iNKT agonist, which is promising for research of antitumor agents and vaccine adjuvants.
    KRN7000 analog 2
  • HY-P990221
    Anti-Mouse IL-17F Antibody (MM17F8F5.1A9)
    		Inhibitor
    Anti-Mouse IL-17F Antibody (MM17F8F5.1A9) is a mouse-derived IgG1, κ type antibody inhibitor, targeting to mouse IL-17F.
    Anti-Mouse IL-17F Antibody (MM17F8F5.1A9)
  • HY-165484
    AVP-13358
    		Inhibitor
    AVP-13358 is an orally active IgE inhibitor that effectively suppresses immunoglobulin E (IgE)-mediated immune responses, with IC50 values of 8 and 3 nM for IgE inhibition in vivo and in vitro in BALB/c mice, respectively. AVP-13358 acts directly on T cells, inhibiting the production and release of IL-4, IL-5, and IL-13. It also targets other markers critical for the development of allergic responses, including the B cell IgE receptor (CD23) in human monocytes and the CD23 and IL-4 receptors in mouse B cells. AVP-13358 can be used in research related to anti-allergic responses.
    AVP-13358
  • HY-RS06670
    IL10 Human Pre-designed siRNA Set A
    		Inhibitor

    IL10 Human Pre-designed siRNA Set A contains three designed siRNAs for IL10 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
    IL10 Human Pre-designed siRNA Set A
    IL10 Human Pre-designed siRNA Set A
  • HY-160026
    IL-17 modulator 8
    		Modulator
    IL-17 modulator 8 (compound 286) is an orally active modulator of IL-17. IL-17 modulator 8 significantly reduces IL-6, IFN-γ, and edema. IL-17 modulator 8 can used in study arthritis.
    IL-17 modulator 8
  • HY-121743
    Ro26-4550
    		Antagonist
    Ro26-4550 is a low micromolar antagonist of IL-2/IL-2Rα binding with an IC50 value of 3 μM.
    Ro26-4550
  • HY-N3979
    Grossamide
    		Inhibitor
    Grossamide is a natural product that can be isolated from fructus cannabis, the dried fruit of Cannabis sativa L.. Grossamide has anti-neuroinflammatory effects.
    Grossamide
  • HY-173180
    5-LOX-IN-8
    		Inhibitor
    5-LOX-IN-8 is a 5-LOX inhibitor with anti-inflammatory activity. 5-LOX-IN-8 suppresses IL-6, IL-1β, TNF-α and IFN-γ in macrophages and reduces IL-8 secretion in SW480 cells. 5-LOX-IN-8 reduces disease activity in a DSS colitis model. 5-LOX-IN-8 can be used for research of inflammatory bowel disease (IBD).
    5-LOX-IN-8
  • HY-B0809B
    Theophylline sodium acetate
    		Inducer
    Theophylline (1,3-Dimethylxanthine) sodium acetate is a potent phosphodiesterase (PDE) inhibitor, adenosine receptor antagonist, and histone deacetylase (HDAC) activator. Theophylline (1,3-Dimethylxanthine) sodium acetate inhibits PDE3 activity to relax airway smooth muscle. Theophylline (1,3-Dimethylxanthine) sodium acetate has anti-inflammatory activity by increase IL-10 and inhibit NF-κB into the nucleus. Theophylline (1,3-Dimethylxanthine) sodium acetate induces apoptosis. Theophylline (1,3-Dimethylxanthine) sodium acetate can be used for asthma and chronic obstructive pulmonary disease (COPD) research.
    Theophylline sodium acetate
Cat. No. Product Name / Synonyms Species Source
Cat. No. Product Name / Synonyms Application Reactivity
Interleukin Related Isoform Comparison

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